diff --git a/drivers/i2c/busses/i2c-imx-lpi2c.c b/drivers/i2c/busses/i2c-imx-lpi2c.c
index 2a0962a0b441..d882126c1778 100644
--- a/drivers/i2c/busses/i2c-imx-lpi2c.c
+++ b/drivers/i2c/busses/i2c-imx-lpi2c.c
@@ -592,6 +592,13 @@ static bool is_use_dma(struct lpi2c_imx_struct *lpi2c_imx, struct i2c_msg *msg)
 	if (!lpi2c_imx->can_use_dma)
 		return false;
 
+	/*
+	 * A system-wide suspend or resume transition is in progress. LPI2C should use PIO to
+	 * transfer data to avoid issue caused by no ready DMA HW resource.
+	 */
+	if (pm_suspend_in_progress())
+		return false;
+
 	/*
 	 * When the length of data is less than I2C_DMA_THRESHOLD,
 	 * cpu mode is used directly to avoid low performance.