diff --git a/drivers/mailbox/pcc.c b/drivers/mailbox/pcc.c
index d8739eca5ac0..967eb249f40d 100644
--- a/drivers/mailbox/pcc.c
+++ b/drivers/mailbox/pcc.c
@@ -467,6 +467,12 @@ static int pcc_startup(struct mbox_chan *chan)
 	unsigned long irqflags;
 	int rc;
 
+	/*
+	 * Clear and acknowledge any pending interrupts on responder channel
+	 * before enabling the interrupt
+	 */
+	pcc_chan_acknowledge(pchan);
+
 	if (pchan->plat_irq > 0) {
 		irqflags = pcc_chan_plat_irq_can_be_shared(pchan) ?
 						IRQF_SHARED | IRQF_ONESHOT : 0;